June 18, 2018
VIA EDGAR
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
| Re: | AVROBIO, Inc. |
Registration Statement on Form S-1 (File No. 333-225213) (the “Registration Statement”)
Ladies and Gentleman:
In connection with the above-referenced Registration Statement, and pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), we hereby join in the request of AVROBIO, Inc. that the effective date of the Registration Statement be accelerated so that it will be declared effective at 4:00 p.m. Eastern Time on June 20, 2018, or as soon thereafter as practicable.
Pursuant to Rule 460 under the Act, please be advised that we and the other prospective underwriters have distributed approximately 2,911 copies of the preliminary prospectus dated June 11, 2018 (the “Preliminary Prospectus”) through the date hereof to underwriters, dealers, institutions and others.
In connection with the Preliminary Prospectus distribution for the above-referenced issue, we hereby confirm that we are, and the other prospective underwriters have confirmed that they are, complying with the 48-hour requirement as promulgated by Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.
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| Very truly yours,
| ||
| MORGAN STANLEY & CO. LLC | ||
| COWEN AND COMPANY, LLC | ||
| WELLS FARGO SECURITIES, LLC | ||
| As Representatives of the several Underwriters | ||
| MORGAN STANLEY & CO. LLC. | ||
| By: | /s/ Albert Hwang | |
| Name: | Albert Hwang | |
| Title: | Managing Director | |
| COWEN AND COMPANY LLC | ||
| By: | /s/ Jason Fenton | |
| Name: | Jason Fenton | |
| Title: | Managing Director | |
| WELLS FARGO SECURITIES, LLC | ||
| By: | /s/ David Herman | |
| Name: | David Herman | |
| Title: | Director | |
[Signature Page to Request for Acceleration of Effectiveness]